The relationship of metabolic syndrome (MetS) and its components with the risk of developing osteoarthritis (OA) has contradictory evidence. To address this, researchers conducted a study investigating this relationship in 370,311 individuals (median age: 56.45 years) for about 12.48 years. During the study, 45,581 individuals were diagnosed with OA. MetS, central obesity, and hyperglycemia were associated with an increased risk of developing OA by 15%, 58%, and 13%, respectively.
In addition, dyslipidemia, particularly the level of triglycerides (hazard ratio [HR] – 1.07) and high-density lipoprotein (HR – 1.05), was also mildly associated with OA risk. Furthermore, the individuals with high polygenic risk scores were at an increased risk of developing OA, and the risk increased by 35% for individuals with MetS and elevated C-reactive protein levels. The study confirmed the association…
