Complicated skin and skin structure infections (cSSSIs) are a group of very commonly found bacterial infections that require frequent hospitalization. The causative agents include Gram-positive cocci (Streptococci and Staphylococci), Gram-negative rods, and anaerobic bacteria. Treatment with antimicrobials forms an integral part of the management strategy for these infections. This Journal Watch describes the CANVAS 1 trial, which evaluated the efficacy of ceftaroline fosamil monotherapy in the treatment of cSSSIs.
What was the need for this study? Treatment of complicated skin and skin structure infections (cSSSIs) have become quite difficult due to the emergence of organisms like methicillin-resistant S. aureus (MRSA). Although vancomycin was considered the treatment of choice in such infections, the increasing antibiotic resistance coupled with significant morbidity has led to an…
