A Dried Blood Spot (DBS) test for screening inherited metabolic disorders in newborns employs a convenient way of microsampling, an especially important feature in remote healthcare and at-home sampling. However, the lack of reference values and measurement bias makes it limited to screening and unreliable for making medical decisions. A Korean institute has developed Certified Reference Materials (CRMs) for DBS with complete measurement traceability to the International System of Units, allowing accurate and reliable measurement of target compounds.
The proposed bias-free measurements provide eight certified values and ten reference values for amino acids, glucose, galactose, and acylcarnitines, which are diagnostic markers of inherited metabolic disorders , including phenylketonuria, hyperprolinemia, and maple syrup urine disease. This first-ever DBS CRMs has made DBS test an…
