Disorders of neuromuscular junction transmission and metabolic diseases cause muscle fatigability, characterized by failure to sustain the force of muscle contraction (peripheral fatigue). Enhanced perception of effort and limited endurance of sustained physical and mental activities are the main characteristics of central fatigue.
This article serves as a quick checklist for assessment of Neurological Fatigue. POSSIBLE PATHOPHYSIOLOGY Proinflammatory syctokines TNF alpha Interleukin 1beta and 6 Dysfunction of the hypothalamo-pituitary-adrenal (HPA) axis Imparied astroglial metabolism Reduced noradrenaline and serotonin levels CENTRAL CAUSES Cerebrovascular disease (CVD) Cerebral vasculitis Cerebral palsy (CP) Neurosarcoidosis Hypothalamic/pituitary lesions Intracranial infections Metabolic encephalopathy Migraine Mitochondrial disease Multiple sclerosis (MS) Parkinson’s disease (PD)…
