Common variable immunodeficiency (CVID) , also known as ‘ common variable hypogammaglobulinemia ’ is a state of immunodeficiency in which there is low production of antibodies. It is estimated that 1 in 25,000 to 1 in 50,000 are affected by CVID worldwide. Although the method of diagnosis of this disease is well established in adults, there has been no investigation of the features of early onset of CVID in the younger population.
Since the symptoms of the disease vary from one child to another, CVID is referred to as a 'variable group of disorders'. What causes CVID in children and what are the consequences? Etiology is unknown in almost 90% of cases In the remaining 10% of cases, CVID is likely caused by both environmental (specific environmental factors still unclear) and genetic factors (mutation in genes involved in the development and function of B cells) Mutations in the genes…
