Widely used to alleviate moderate-to-severe acute pain, oxycodone is an effective analgesic for many types of pain and is especially useful for paroxysomal spontaneous pain, steady pain, allodynia associated with postherpetic neuralgia, and it is also increasingly used in the management of cancer-related and chronic pain. Further, Oxycodone has been found to also improve the quality of life of patients with pain. Drug Metabolism Metabolized by CYP3A4 and CYP2D6 in the liver, acting in 10-30 minutes, and, reaching its peak plasma levels in 30-60 minutes, only 10% of Oxycodone is excreted in urine unchanged.
This makes it susceptible to pharmacokinetic drug interactions leading to potentially dangerous adverse effects such as respiratory depression. The drug is distributed to skeletal muscles, liver, intestinal tract, lungs, spleen and brain. Drug Action Oxycodone is widely used to…
