Type 2 diabetes is one of the most common chronic diseases worldwide. In most cases, it is linked to obesity, insulin resistance, genetics, and lifestyle factors. However, clinicians should remember that, in a small subset of patients, new-onset diabetes or a sudden deterioration in previously stable diabetes may be an early warning sign of pancreatic cancer. Several studies have demonstrated a bidirectional relationship between diabetes and pancreatic cancer.
While long-standing diabetes is a recognized risk factor for pancreatic malignancy, pancreatic cancer itself can induce metabolic changes that manifest as new-onset diabetes or rapidly worsening glycemic control. Research has shown that a significant proportion of pancreatic cancer diagnoses occur within the first year after the onset of diabetes. Patients who require unexpectedly aggressive escalation of therapy—from oral agents…
