Case presentation: A 57-year-old woman presented with a 10-year history of multiple skin lesions, intermittently painful, especially with cold and pressure. History: The patient’s medical history was significant for a hysterectomy due to uterine leiomyomas 11 years ago. Considering family history, her sister had both skin and uterine leiomyomas. Physical examination: Erythematous-to-brownish papules and nodules, with a smooth surface, grouped in the upper back.

Immunohistochemistry showed positivity for smooth muscle actin. A biopsy of a papule from the back was taken for a histological examination. Figure: (L to R):   Cutaneous leiomyomas grouped in the upper back; Cutaneous leiomyoma (H and E, ×100); Cytoplasmic expression of smooth muscle actin (Immunohistochemistry, ×100) *This Case Challenge is from Docplexus Editorial Team and is meant for educative purposes only. Source: Indian…