Several studies suggest that omega-3 supplementation , alone or combined with antidepressants, may provide modest improvements in depressive symptoms in adults with severe depression. However, evidence in adolescents and young adults remains inconclusive. To address this gap, a study investigated the effects of omega-3 supplementation on depressive symptoms in 257 youths with moderate-to-severe major depressive disorder (MDD). The study found that scores on the Children’s Depression Rating Scale–Revised (CDRS-R) decreased similarly in both the omega-3 and placebo groups at 12 weeks (45.9 vs. 46.0) and 36 weeks (36.5 vs.
36.8). Response rates (≥30% reduction in CDRS-R scores; 31.2% vs. 39.1%) and remission rates (CDRS-R score ≤28; 31.9% vs. 41.1%) did not differ significantly between groups. No significant differences were observed between the groups in suicidality or other secondary…
