Antimicrobial therapy causes symptom regression and a reduction in urinary tract inflammation in patients with chronic lower urinary tract symptoms (LUTS) and pyuria reported a recent study published in the International Urogynecology Journal. The LUTS may be linked with chronic urinary tract infection (UTI) which remains undetected by routine diagnostic tests. The study involved treatment of 624 women with the mean age of 53.4 years suffering from chronic LUTS and pyuria.
The treatment involved full-dose first-generation antibiotics for UTI, such as cefalexin, nitrofurantoin, or trimethoprim, were combined with methenamine Hippurate. The treatment reduced in total LUTS (F = 98; p = 0.0001), 24-h frequency (F = 75; p = 0.0001), urinary urgency (F = 90; p = 0.0001), lower urinary tract pain (F = 108; p = 0.0001), voiding symptoms (F = 10; p = 0.002), and pyuria (F = 15.4; p = 0.0001).…
