Regular exercise is highly encouraged and its perks in weight loss, regulating appetite, and overall health are well-known. However, it could be risky in advanced age, frailty, osteoporosis , and osteoarthritis . Such high-risk populations may benefit from interventions based on molecular-level understanding of how exercise affects the body.
A US study has identified a molecule Lac-Phe, produced during exercise in mice plasma. Lac-Phe is synthesized From lactate and phenylalanine by the enzyme – CNDP2 In macrophages, monocytes, and other immune and epithelial cells in different organs In mice on a high-fat diet, a high dose of Lac-Phe suppressed food intake by about 50% compared to control mice within 12 hours without affecting their energy expenditure , whereas ten days of administration decreased cumulative food intake, body weight, and glucose intolerance. Post-exercise increase in…
