Doxorubicin is a chemotherapy drug widely used for the treatment of various types of cancers, but it carries a harmful side effect. The drug causes a dose-dependent heart toxicity that can lead to congestive heart failure. Indian Researchers at the University of Alabama in the US conducted a study on mice and found that doxorubicin induces fibrosis in the heart, increase apoptosis and impairs the pumping of the heart which leads to congestive heart failure. It also induced a wasting syndrome in the heart and spleen Researchers have found that doxorubicin disturbs the metabolism in the spleen and heart.
This dysregulation in immunometabolism leads to advanced heart failure. In the study, doxorubicin induced irreversible dysregulation leads to lower the levels of the enzyme like lipoxygenases and cyclooxygenases in the left ventricle of the heart. In the spleen, doxorubicin targeted a…
