Osteoarthritis (OA) is a major health burden affecting more than 350 million individuals globally. 1 The currently available therapeutic strategies primarily focus on the management of symptoms. Effective therapeutic options aimed at slowing or halting the progression of the disease have not yet been developed. Need for the study Recent studies have elaborated on the various secondary effects of metformin, a commonly used diabetes medication, including its analgesic and anti-inflammatory activity.
Animal models and small-scale human preclinical studies have also illustrated the potential of metformin in slowing the progression of osteoarthritis in adults with type 2 diabetes (T2DM). However, studies focusing on the preventive effect of metformin on OA have not yet been conducted. The following Journal Watch article summarizes a study entitled “ Development of Osteoarthritis in…
