Introduction: In this research, we studied the effect of topical nasal decongestant (Xylometazoline 0.1% solution) on serial measurements of nasal peak ow rates in a cohort of patients who were suffering from acute sinusitis. Materials and Methods: A population of 90 patients was chosen from our regular out-patient clinics who were suffering from acute sinusitis based on a clinical diagnostic criterion. A baseline Nasal Peak Flowmetry was done. This was followed by a common decongestant (Xylometazoline 0.1% solution) spray application.
Subsequently, Nasal Peak Flowmetry was done after 10, 25, 60, 120, 240 and360 minutes and the readings were plotted and analysed. Result: From the AUC Curves, it can be inferred that the maximum decongestant action of Xylometazoline 0.1% solution is seen 1 hour after application and the rise in decongestion reaches a plateau by 2 hours. Readings almost…
