The history of Egyptian guidelines for venous disorders started more 14 centuries B.C., as mentioned in the Ebers' papyrus when the ancient Egyptian doctor dened varicose veins as “Serpentine wings” and also recommended the method to deal with these varices “do not touch these dilated veins lest uncontrollable bleeding will occur.” Burden of CVD A recently published comprehensive systematic review on the global epidemiology of CVD identified 32 studies from six continents including >300,000 adults. It showed that the pooled prevalence of C2 disease in Africa was (5.5%).
C2 disease had a progression rate of 22% developing a venous leg ulcer (VLU) in six years. Although the progression of CVD is important, few epidemiological studies have investigated its natural history.
