Doses for most drugs are determined from population-level information, resulting in a standard ‘one-size-fits-all’ dose range for all individuals. This article outlines the key findings of a recent study which explores how doses can be personalized using the individuals’ pharmacokinetic-pharmacodynamic profile and its particular application in children. At present individualized therapy and personalized dosing have become a necessary outcome of the new precision medicine initiative.
In this regard, Pharmacometrics is an emerging discipline that quantifies drug, disease and trial information to aid efficient drug development and/or regulatory decisions. Mainly drug models describe the relationship between exposure (or pharmacokinetics), response (or pharmacodynamics) for both desired and undesired effects, and individual patient characteristics. The Bayesian forecasting approach, based on…
