Disruptions in circadian rhythms have been linked to adverse cardiometabolic outcomes. To examine this relationship, a large prospective study assessed the impact of chronotype (preferred timing of daily activity) on cardiovascular disease (CVD) risk in 322,777 adults aged 39–74 years without baseline CVD. Cardiovascular health was evaluated using the American Heart Association’s Life’s Essential 8 (LE8) score, which incorporates eight modifiable CVD risk factors. Individuals with a definite evening chronotype had a 79% higher prevalence of poor cardiovascular health (LE8 score <50) compared with those with an intermediate chronotype.
Over a median follow-up of 13.8 years, 17,584 incident CVD events occurred. Compared with intermediate chronotype, the hazard ratio for total CVD was 1.16 for definite evening types and 1.03 for definite morning types. Mediation analysis showed that…
