Synopsis Isoniazid for 6 or 9 months can prevent active tuberculosis; however, its benefits are reduced due to poor regimen completion rate and hepatotoxic effects. The present study aims to compare the effectiveness and efficacy of a 4-month regimen of rifampin with a 9-month regimen of isoniazid for the prevention of active tuberculosis. This week’s “MED FACT” discusses a clinical trial from The New England Journal of Medicine, “ Four Months of Rifampin or Nine Months of Isoniazid for Latent Tuberculosis in Adults ” August 2018. Authors: D. Menzies, M.
Adjobimey, R. Ruslami et. al. Key Takeaways: The 4-month regimen of rifampin is a good option for the prevention of active tuberculosis as compared to isoniazid as it has a higher treatment completion rate and less toxic effects. Objective: To compare the effectiveness and efficacy of a 4-month regimen of rifampin with a 9-month…
