Frailty is an important geriatric syndrome characterized by age-associated declines in physiologic reserve and function across multiorgan systems, leading to increased vulnerability for adverse health outcomes. Significant progress has recently been made in understanding the pathogenesis of frailty. As a result, an understanding of the biologic basis and complexity of frailty syndrome is essential. Chronic inflammation is likely a key pathophysiologic progression that pays to the frailty syndrome directly and indirectly.
The other intermediate physiologic systems involved are musculoskeletal, endocrine, and hematologic systems. The frailty phenotype defines frailty as a distinct clinical syndrome meeting three or more of five phenotypic criteria. While the frailty index defines frailty as cumulative deficits identified in a comprehensive geriatric assessment. Frailty Frailty is a…
