Background: Oral Lichen Planus (OLP) is a inflammatory condition affecting the mucosal mouth surface and often co-diagnosed with xerostomia. OLP affects 0.5% to 2% of the population. Treatments for OLP are usually palliative to control the inflammatory state of the disease, requiring life-long supportive care. When not controlled, OLP can lead to the formation of precancerous lesions which in some cases progress to oral cancer, making early preventative intervention extremely important.
Previous studies have identified tctP (a tumor reversion gene or histamine release factor) to be an important biomarker for OLP. The uncontrolled expression of this gene has been observed to be an indicator for a poor prognosis among the OLP patients with oral cancer. Understanding the genetic mechanisms associated with the TCTP pathway could lead to the identification of potential targets for…
