A 36-year-old woman visited her primary care physician with complaints of fatigue and occasional nocturia. The patient had a history of obesity and hypertension, along with a family history of type 2 diabetes mellitus (T2DM). On the evaluation of her diabetes status, laboratory results were unremarkable, with a fasting glucose concentration of 124 mg/dL (7.0 mmol/L). Her HbA1C was tested by immunoassay on two separate occasions that yielded normal results (5.3% and 5.1%, respectively).

The patient was assured that she was non-diabetic and was advised for a follow-up after 3 months. After 3 months, the patient relocated to a different state for employment reasons. She presented to a new primary care physician for a workplace physical examination. Her reports revealed the following: Fasting glucose concentration: 142 mg/dL (7.8 mmol/L) 75-g, 2-hour oral glucose tolerance test: 220 mg/dL…