Granular parakeratosis is a rare disorder characterized by hyperkeratosis, parakeratosis, and retention of keratohyalin granules in the stratum corneum. It is an idiopathic and benign skin disease with an incidence of approximately 0.005%. Granular parakeratosis tends to affect women older than 40 years but has been described in both sexes and a range of ages. Patients classically present with shorter than 1-year duration of eruptive red to brown hyperkeratotic papules and plaques in intertriginous areas that can be asymptomatic, pruritic, or painful.
Involvement can be unilateral or bilateral. Relevant differential diagnoses include Hailey-Hailey disease, Darier disease, Dowling-Degos disease, pemphigus vegetans, intertrigo, dermatophytosis, and candida. Management The disease is often self-limiting, but according to several published case reports, the following treatments are…
