Clostridium difficile infection is the major cause of antibiotic-associated diarrhea and colitis with an ever-increasing prevalence in India. Recently ICMR has released the recommendations related to the first-line and alternative treatment options for C. difficile Colitis based on the disease severity and frequency. Antibiotics mostly associated with C. difficile infections are Fluroquinolones, Clindamycin, Penicillins (Broad spectrum), Cephalosporins (Broad spectrum).
On the other hand, Antimicrobials least associated with C. difficile infections are: Macrolides Sulphonamides Trimethoprim Aminoglycosides Tetracycline Tigecycline Chloramphenicol Metronidazole TREATMENT REGIMEN: Mild condition Initial antibiotics: Metronidazole 400 mg thrice daily oral dose for 10 – 14 days. Alternate antibiotics: Vancomycin 125 mg four times daily oral dose. Any ongoing antibiotics should be ceased if…
