Von Willebrand disease (VWD) is a bleeding disorder caused due to the deficiency or defect in Von Willebrand Factor (VWF). VWF is a glycoprotein that is synthesized in megakaryocytes and endothelial cells. It acts as a carrier for factor VIII and helps in platelet binding, and adhesion to endothelial cells post vascular injury. VWD can be inherited or acquired. The inherited phenotypic forms of VWD include Type 1 (caused by partial quantitative deficiency of VWF), Type 2 (caused by several qualitative defects in VWF, and Type 3 (caused by a complete quantitative defect in VWF).
Affected people may complain of prolonged bleeding from mucosal surfaces, excessive bruising, and prolonged bleeding after minor trauma. Answer the following question on Von Willebrand Factor Which of the following statement is CORRECT regarding Von Willebrand factor activity? A. It is a quantitative analysis for…
