Depression in pediatric patients can be addressed by behavioral therapy or medication therapy. In severe cases, pediatric patients are treated with antidepressants of two major classes SSRIs or TCAs. In this article we will have a look at imipramine, a TCA used in pediatric patients. Imipramine is a tetracyclic antidepressant (TCA) commonly used in pediatric patients. Imipramine hydrochloride is a drug from dibenzazepine group of compounds.
Varieties of other compounds of this group are used to treat major depression. In addition imipramine is also used to treat enuresis. Following is the additional information for this very useful drug. Clinical Pharmacology of Imipramine: The clinical effect of imipramine is hypothesized due to potentiation of adrenergic synapses by blocking uptake of norepinephrine at nerve endings. The mode of action of the drug in controlling childhood enuresis is…
