Psoriasis , a chronic inflammatory skin disorder, has been suggested to be linked with cardiovascular, kidney, and metabolic (CKM) health, though evidence remains limited. To address this gap, a study evaluated the associations between cardiovascular–kidney–metabolic (CKM) status, genetic risk, and the risk of developing psoriasis, as well as the impact of CKM syndrome on life expectancy in patients with psoriasis, involving 392,454 participants. The study found that the risk of developing psoriasis increased with higher CKM stages, with multivariable-adjusted HRs of 1.21, 1.38, 1.64, and 1.72 for CKM stages 1, 2, 3, and 4, respectively, compared to stage 0.
Participants with CKM stage 4 and high genetic risk had the highest risk of psoriasis (HR = 2.82) compared to those with stage 0 and low genetic risk. A significant positive additive interaction was observed between advanced CKM…
