Trigeminal neuralgia (TN) is considered one of the most debilitating disorders. Several medications are available to provide relief from pain. However, very few are evaluated for their efficacy in controlling of refractory trigeminal neuralgia. In this regard, a recent study compared ketamine infusion versus lidocaine infusion in the management of intractable trigeminal neuralgia.

Trigeminal neuralgia is considered one of the most incapacitating disorders characterized by brief, intense, and stabbing pain affecting one or more divisions of the trigeminal nerve. According to the various treatment guidelines, carbamazepine or oxcarbazepine are the first pharmacological choice of treatment for TN and baclofen is the second choice. However, some patients have been reported to become unresponsive to medication despite adequate treatment. Also, sometimes, patients cannot tolerate the…