Chronic ocular hypotony remains difficult to manage, and visual outcomes are often poor despite medical or surgical intervention. While prior reports have described the use of intravitreal viscoelastic injections to address structural hypotony, these approaches have largely lacked standardized protocols and systematic outcome assessment. To refine this strategy, investigators evaluated intravitreal hydroxypropylmethylcellulose (HPMC) injections (70 µL to 1,400 µL) using a structured treatment protocol in eight patients with chronic structural hypotony.
At one year, 87.5% of eyes showed improvement in best-corrected visual acuity, while one eye remained stable. Baseline visual acuity ranged from 0.3 to 1.7 LogMAR and improved to a final range of 0.1 to 1.6 LogMAR. Notably, intraocular pressure (IOP) increased in 87.5% of eyes, rising from an initial range of 1 to 5 mm Hg to 3 to 23 mm…
