Intracytoplasmic sperm injection (ICSI) was originally developed for treating severe male infertility . However, ICSI is increasingly being used to treat non-severe male infertility. A study examined whether ICSI is more beneficial than conventional in vitro fertilization (IVF) among couples (n = 2,329) with non-severe male infertility. In the study, live birth occurred in 33.8% of couples in the ICSI group and 36.6% of couples in the IVF group after first embryo transfer .
The total number of live births, including after multiple embryo transfers, occurred in 45% of couples in the ICSI group and 51% of couples in the IVF group. Furthermore, two neonatal deaths occurred in the ICSI group and one in the IVF group. This study demonstrates that ICSI cannot improve the live birth rate in couples with non-severe male infertility compared to IVF and recommends against the use of ICSI in this…
