The post-acute sequelae of COVID-19 (PASC), commonly known as ' Long COVID ,' present a substantial global health challenge with unknown pathophysiology and no established treatments. A study has postulated that a comprehensive mechanism of serotonin reduction in long COVID patients could link the four hypotheses responsible for the etiology of the condition, including viral persistence, chronic inflammation, hypercoagulability, and autonomic dysfunction.
According to researchers, measuring serotonin levels could help tell the difference between people who have fully recovered from COVID-19 and those experiencing long COVID. By studying groups of people, testing on animals with viral infections, and growing simplified versions of organs in the lab (organoids), it was found that the virus's genetic material (RNA) and the body's response to it (interferon) lead to a drop in serotonin…
