Is There an Association Between Serum Copper Levels and the Onset of CVD?

Dysfunctional copper metabolism is shown to be associated with neurodegenerative disease, cancer, and cardiovascular disease (CVD). 1 However, the impact of serum copper (S-Cu) levels on CVD has not been studied well. To determine whether S-Cu levels are associated with the onset of the first CVD event, Spanish researchers analyzed medical records of 207 CVD cases and 436 controls from a clinical trial. 2 In the follow-up of 4.8 years, the S-Cu concentrations of all participants (aged 55-80 years) were between the reference values, 750 mg/L and 1450 mg/L. However, the mean S-Cu concentration in men with CVD, but not in women, was higher compared to controls (1014.1 mg/L vs.

959.3 mg/L). Furthermore, men had the highest multivariable-adjusted odds ratio for CVD compared to women (2.36 vs. 0.43). This study indicates that examining S-Cu levels in men, especially those at risk of…