A retrospective study of 96 children with pediatric intramedullary spinal cord tumors (PIMSCTs) has identified key clinical and pathological factors associated with survival and neurological outcomes. The analysis included patients who underwent surgical treatment between 2015 and 2024, with the thoracic spine emerging as the most common tumor location. Most patients presented with mild neurological deficits at admission, and astrocytoma was the most frequently observed tumor type. Researchers found that overall survival was significantly associated with the World Health Organization (WHO) tumor grade, while tumor length did not influence survival.
Elevated expression of the biomarkers Ki-67 and p53 was linked to poorer postoperative survival. Notably, H3K27M mutation status did not significantly affect survival in high-grade spinal astrocytomas. The study also revealed that tumor…
