Liposomal Bupivacaine is non-opioid anesthetic commonly used for post-operative pain management. Many studies have shown that non-opioid bupivacaine is closely related with a decrease in opiate use after total knee arthroplasty. The new study also suggests that liposomal bupivacaine is better than immediate-release bupivacaine in reducing pain as well as side effects. Liposomal bupivacaine is one the anesthetic used in the long-term management of pain.
The development of liposomal bupivacaine is based on the idea of increase residence of drug of interest. The drug (in this case anesthetic bupivacaine) is bound within a carrier molecule to increase its time of residence at the site of action. In the formulation of liposomal bupivacaine, bupivacaine is loaded in multivesicular liposomes. It increases the release duration of the drug and delays the peak plasma concentration when compared…
