The major depressive disorder (MDD) is the leading cause of mortality and disability in moderate to high-income countries. It is evidenced that individuals with the MDD often present with increasing persistence of major depressive episodes. Moreover, diagnosed depressive patients are mostly treated with antidepressants, psychotherapy and the untreated individuals suffer from recurrent depressive episodes as they get older.
However, there is a less evidence for the neuroprogression which enhances brain pathology with longer duration of illness. Is MDD associated with the neurodegenerative disease if left untreated for longer duration? Source: Radiology Business
