Long-term use of metformin may decrease the risk of colorectal cancer in diabetes patients reported a recent clinical study published in a journal Cancer Epidemiology, Biomarkers & Prevention. Various epidemiologic studies have already reported a strong inverse association between metformin use and risk of colorectal cancer. The current cohort clinical study re-examined this link using methods to minimize these time-related biases. The study involved 47,351 with diabetes and without a history of cancer or metformin use.
The follow-up for the incidence of colorectal cancer was conducted from January 1, 1997, to June 30, 2012. The study demonstrated no link between use of metformin and colorectal cancer risk (HR, 0.90; 95% CI, 0.76–1.07) However, long-term use i.e. ≥ 5.0 years was linked with decreased risk of colorectal cancer in the full population (HR, 0.78; 95% CI, 0.60–1.02), among…
