Low circulating vitamin D levels in later life have been associated with an increased risk of cognitive impairment and clinical dementia , but their significance in early midlife remains uncertain due to limited evidence. To address this gap, a study evaluated whether early midlife serum vitamin D levels are linked to subsequent tau and amyloid burden on brain-PET imaging in 793 dementia -free adults. The study found that among participants with 424 undergoing amyloid and 369 tau-PET imaging, the mean interval between blood sampling and imaging was 16 Β± 2 years.
Higher serum 25(OH)D levels were associated with lower global (Ξ² = β0.022) and composite tau deposition (Ξ² = β0.023), but not with amyloid burden. These findings suggest that higher early midlife serum 25(OH)D levels may be associated with lower later-life tau deposition, indicating vitamin D as a potentially modifiable factorβ¦
