A 24-year-old male presented with multiple episodes of migraine associated with hemiparesis, paraesthesia, prolonged somnolence, aphasia and confusion, which he had been having since the age of 4 years. He did not report visual disturbances or dysarthria. Each episode was characterized by a progressive reduction of symptoms and a full recovery. He was an only child. His father presented with some episodes of migraine, which, however, were never associated with other symptoms. Also, his grandmother (of paternal origin) had uncomplicated episodes of migraine.
His family history was otherwise unremarkable. The patient had 2 episodes of a migraine per week. The patient was extremely somnolent after these episodes (up to 24–48h). MRI imaging and laboratory findings Repeated brain imaging (including also MRI angiography) were normal. Routine laboratory studies were within normal limits,…
