Mycosis fungoides (MF) is a form of non-Hodgkin lymphoma characterized by papulosquamous patches or plaques. It can rarely advance to become tumors with involvement of the lymphatic system and other viscera. Many skin-directed therapies such as topical chemotherapeutic agents, phototherapy, methotrexate etc. are used as first-line treatment. Among them, phototherapy is one of the cornerstones in the treatment of early-stage MF.
Narrowband UV-B (NBUVB, 311nm) and psoralen–UV-A (PUVA, 320-340nm) are the most commonly used modalities of phototherapy. Both differ in their mechanism of action, as well as electromagnetic and biological properties. In recent years, NBUVB has become popular due to the fewer adverse effects and lesser risk of carcinogenesis compared to the PUVA. Despite the availability of guidelines on phototherapy for the treatment MF, there is a lack of evidence regarding the…
