The metabolic dysfunction, dyslipidemia, and inflammation caused by obesity contribute to the development of a wide variety of disorders and effects on the nervous system. The current article enlists the neurological consequences of obesity.
Substantial increases in adipose mass, particularly in the visceral depots, contribute to adipose tissue dysfunction and promote metabolic disease via a low-grade metabolic inflammation that underlies systemic metabolic dysfunction. Effect of obesity on CNS Central nervous system Structural effects Brain atrophy and reduced gray matter volume in frontal and temporal lobes, and enlarged orbitofrontal white matter Decreased volume of the hippocampus and hypothalamus, measured by structural MRI Physiological effects Cerebral ischemia and hypoperfusion Altered brain metabolism and nerve function Clinical effects Altered feeding behavior and satiety…
