Case Presentation A 60-year-old man with a one-year history of metastatic melanoma was evaluated for new cutaneous lesions. The primary melanoma originated from a hyperpigmented lesion on the hard palate, with known metastatic involvement of the neck.
Current Treatment Receiving combination therapy with immune checkpoint inhibitors (nivolumab and ipilimumab) Concurrent chemotherapy with cisplatin and temozolomide Presenting Complaint Development of multiple new pigmented skin lesions eight months after initiation of treatment Clinical Findings Bluish macule-like lesions of varying sizes (Cover Image A) Located on the right retroauricular region, neck, and anterior chest Well-defined borders with surrounding vitiligo-like depigmented halos Clinical concern for in-transit melanoma metastases Diagnostic Workup Biopsies performed on two representative lesions (Cover Image B) Histopathology…
