Knee arthroplasty is commonly associated with significant blood loss, and tranexamic acid (TXA ) is widely used to reduce perioperative bleeding. While intravenous administration is effective, oral TXA offers a more convenient and cost-effective alternative. To address the lack of focused evidence, a study compared the efficacy and safety of oral versus intravenous TXA in knee arthroplasty, evaluating outcomes such as blood loss, transfusion needs, and complications, involving 927 patients.
The study found no significant differences between oral and intravenous Tranexamic acid in postoperative hemoglobin (WMD: 0.25), hemoglobin drop (WMD: −0.02), hematocrit (WMD: 0.01), intraoperative blood loss (WMD: 5.5), transfusion rates (odd ratio (OR): 0.89), complications (OR: 0.67), or hospital stay (WMD: −0.03). Operation time was also similar overall (WMD: −0.36), but intravenous TXA given…
