Female sex and having a parent with Alzheimer’s disease (AD), particularly a mother, are associated with a higher risk of developing the condition. However, the relationship between sex, the sex of the affected parent, and AD biomarkers remains unclear. To explore this, a study has examined the association between sex and the sex of an affected parent with various aspects of Alzheimer's pathology in 243 individuals (mean age: 68.3 years) from an AD cohort.
The study found that women exhibited greater tau deposition and a stronger link between global beta-amyloid (Aβ) and tau deposition than men. Interestingly, individuals with an affected father showed a stronger association between Aβ and tau deposition compared to those with an affected mother. These findings indicate that women and individuals with a paternal history of AD may be more susceptible to Alzheimer’s-related brain changes.…
