PK Analysis Of Triamcinolone Microspheres In Knee OA

Synopsis Intra-articular (IA) corticosteroids relieve osteoarthritis (OA) pain, but rapid absorption into systemic circulation may limit efficacy and produce untoward effects. The present study aims to compare the pharmacokinetics of IA triamcinolone acetonide (TA) extended-release, microsphere-based formulation (FX006) Vs a crystalline suspension (TAcs) in knee OA patients. This week’s “ MED FACT ” discusses a clinical trial from Osteoarthritis and Cartilage, “ Synovial and systemic pharmacokinetics (PK) of triamcinolone acetonide (TA) following intra-articular (IA) injection of an extended release microsphere-based formulation (FX006) or standard crystalline suspension in patients with knee osteoarthritis (OA)” . Authors:  V.B.

Kraus et. al. Key Takeaways In knee OA patients, microsphere-based TA delivery via a single IA injection prolongs SF joint residency, diminishes peak plasma…