Primary ciliary dyskinesia (PCD) is a genetically heterogeneous disorder of motile cilia.It is characterized by ciliary dysfunction and impaired mucociliary clearance, resulting in an array of clinical manifestations, including chronic bronchitis leading to bronchiectasis, chronic rhino-sinusitis , chronic otitis media, situs inversus (in approximately 50% of cases), and male infertility. The incidence of PCD is estimated at 1/16,000 births, based on a prevalence of situs inversus and bronchiectasis. However, few PCD patients carry a well-established diagnosis, which reflects, the limited ability to diagnose this disorder.
This article gives you an insight on the clinical aspects of this entity. The condition now known as Primary Ciliary Dyskinesia (PCD), was first recognized by Kartagener, who described bronchiectasis, nasal polyposis, and chronic sinusitis in a group of patients. The…
