Scientists have developed predictive models based on the levels of specific proteins in blood samples that can determine the probability of developing psychiatric illness in individuals at high risk of psychosis. The study “Development of Proteomic Prediction Models for Transition to Psychotic Disorder in the Clinical High-Risk State and Psychotic Experiences in Adolescence”, has been published in JAMA psychiatry. Researchers identified the baseline differentially expressed proteomic biomarkers in the plasma obtained from patients with a clinically high risk of psychosis vs. the general population.
These subjects were under constant follow up for many years to identify who did and did not experience a psychotic illness using the psychotic assessment tools and interview. In the clinically high risk group, only about 30% to 40% of the individuals experienced psychiatric illness. Based on…
