Pyoderma gangrenosum is a rare inflammatory neutrophilic dermatosis often manifesting as painful ulcers on the lower extremities. Recently, pyoderma gangrenosum has been included within the spectrum of autoinflammatory diseases, which are characterized by recurrent episodes of sterile inflammation without circulating autoantibodies and autoreactive T cells. This article outlines the recent advances in pyoderma gangrenosum.
Pyoderma gangrenosum (PG) is a necrotizing dermatosis that represents a challenge for any clinician, not only for its ability to mimic other dermatoses but also for its lack of response to treatment. Despite the advances that have been made in the treatment of patients with PG, the optimal way in which patients should be managed once diagnosed is yet unclear. Therefore, it is essential to understand the underlying signaling pathways to establish the appropriate and…
