Key Takeaways: - Cancer cells adapt to varying stress conditions through plasticity, including the ability to alter their epithelial and mesenchymal properties. - Transforming growth factor-beta (TGF-ß) is a crucial growth factor that allows cancer cells to gain plasticity through epithelial-mesenchymal plasticity (EMP). - TGF-ß signaling can have both detrimental and beneficial effects on cancer cells, depending on the cellular context. Summary: This paper explores the role of TGF-ß in cancer and its involvement in epithelial-mesenchymal plasticity (EMP).
Cancer cells can acquire plasticity and alter their cell properties through EMP, which allows them to survive in challenging environments. TGF-ß, a multifunctional cytokine, mediates signaling pathways that enable cells to undergo EMP. However, TGF-ß can have both anti-tumor and pro-tumor effects on cancer cells, depending on the…
