Invasive coronary function testing (CFT), which can detect coronary vasomotor disorders in up to 90% of patients with angina and non-obstructive coronary arteries (ANOCA), may offer a more effective approach to early diagnosis and management. To evaluate this potential, the ILIAS ANOCA trial examined whether routine ad hoc CFT, combined with a disease-specific treatment protocol, could safely improve quality of life compared with standard care in 255 patients. The study found that all CFT procedures were completed safely with no adverse events, and vasomotor disorders were detected in 78% of patients.
At 6 months, patients undergoing CFT-guided treatment showed a significantly greater improvement in Seattle Angina Questionnaire summary score (SAQSS) scores an intervention effect of 9.4 units, compared with standard care. These findings suggest that routine CFT during initial invasive…
