Crystallisation of Cholesterol is the most important step towards plaque rupture. Cholesterol crystal also destabilisation of atherosclerotic plaque and cause arterial inflammation. Recently Shamoun published in Eur Heart Journal (2016)37 and explained the possible physiology for Plaque and its rupture. When we describe vulnerable plaque and plaque rupture, we do not know the dynamic events that led to rupture . In the plaque when cholesterol crystallises from a liquid to a solid state, its volume expands.
Sharp-tipped cholesterol crystals within the plaque can perforate the fibrous cap. In addition, cholesterol crystals also trigger local and systemic inflammation After All, Why do we develop Plaques in our coronary or other vessels? The main culprit is the LDL particle, which carries Cholesterol to the arterial wall. When LDL is oxidised, it is taken up by macrophages to become foam…
