Pterygium is a benign lesion usually growing from the nasal side of the conjunctiva onto the cornea. Pterygium surgery is usually done when the symptoms do not respond to conservative treatment. Mitomycin C has been used as a fibroblast proliferation inhibitor during the surgery that reduces the chance of relapse of the pterygium. Though the pathogenesis of pterygium has not been fully clarified, it represents a degenerative response of the fibrous connective tissue to different stimuli.
Among the risk factors, exposure to ultraviolet radiation plays a significant role in inducing damage to the limbal stem cells. As a result, there is a migration of the conjunctiva towards the cornea, chronic inflammation, and fibrovascular tissue formation. Further according to a recent study, it was suggested that there is a mutation in the p53 gene on chromosome 17 as the cause of this disease, and…
